preparation of chitosan nanoparticles loaded by tramadol using ionic gelation method
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Development and testing of novel temoxifen citrate loaded chitosan nanoparticles using ionic gelation method
The goal of the present investigation was to formulate and evaluate chitosan nanoparticles of temoxifen citrate for cancer therapy. Nanoparticles of TMX were prepared using chitosan using ionic gelation method. The concentration of the polymers Chitosan were selected based on the results on preliminary screening. The nanoparticles prepared were evaluated for morphology, loading efficiency, invi...
متن کاملOptimization and development of insulin nanoparticles by new thiolated chitosan derivative with ionic gelation method using a model-based methodology
Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. Oral delivery is the most convenient administration route. However, insulin cannot be well absorbed orally because of its rapid enzymatic degradation in the gast...
متن کاملPreparation of Chlorpheniramine Maleate-loaded Alginate/Chitosan Particulate Systems by the Ionic Gelation Method for Taste Masking
BACKGROUND Chlorpheniramine maleate (CM) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. OBJECTIVES The purpose of this research was to mask the bitter taste of CM by formulating microspheres of the taste-masked drug. MAT...
متن کاملPreparation of Chitosan Nanoparticles Loaded by Dexamethasone Sodium Phosphate
Biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. Chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. The aim of the present investigation was to describe the synthesis and characterization of novel biodegradabl...
متن کاملpreparation of chlorpheniramine maleate-loaded alginate/chitosan particulate systems by the ionic gelation method for taste masking
conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: t...
متن کاملChitosan-based nanoparticles by ionotropic gelation
Ionotropic gelation between chitosan, as the polycation of acidic pH, and TPP (penta sodium triphosphate aka tripolyphosphate) as the anionic oligomeric partner leads to the formation of colloidal systems which can range from approximately 100nm to 2000nm. Depending on the conditions, particles with different properties can be obtained including differences in size, zeta potential, stability at...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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